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Rev. Inst. Med. Trop. Säo Paulo ; 49(5): 331-334, Sept.-Oct. 2007. tab
Article in English | LILACS | ID: lil-467375

ABSTRACT

Chronic meningitism is a less frequent manifestation of neurocysticercosis caused by Taenia solium cysticerci. In the present study we used Co-agglutination (Co-A), a simple and rapid slide agglutination test to detect specific Cysticercus antigen in the 67 cerebrospinal fluid (CSF) samples from patients with chronic meningitis of unknown etiology. The results were compared with that of ELISA for detection of antibodies. Among these samples four (5.97 percent) were positive for Cysticercus antigen by Co-A test and six (8.95 percent) were positive for antibodies by ELISA. Two samples were positive by both Co-A and ELISA, two were positive only by Co-A and four were positive only by ELISA. In the present study, although Cysticercus antigen and antibodies were present in CSF samples from eight (11.94 percent) patients, we cannot affirm that all the cases of chronic meningitis are due to cysticercosis, but for any case of chronic meningitis of unknown origin, it would be useful to consider the possibility of cysticercal meningitis.


Meningite crônica é manifestação pouco freqüente de neurocisticercose causada por cisticerco de Taenia solium. No presente estudo utilizamos co-aglutinação (Co-A) um teste simples e rápido de aglutinação para detectar antígeno específico de Cysticercus nas 67 amostras de fluido cerebrospinal (CSF) de pacientes com meningite crônica de etiologia desconhecida. Os resultados foram comparados com os de ELISA para detecção de anticorpos. Dentre estas amostras quatro (5,97 por cento) foram positivas para antígenos de Cysticercus pelo teste Co-A e seis (8,95 por cento) foram positivas para anticorpos por ELISA. Duas amostras foram positivas por ambos Co-A e ELISA, duas foram positivas somente por Co-A e quatro foram positivas somente por ELISA. No presente estudo embora antígenos e anticorpos de Cysticercus estivessem presentes nas amostras de CSF de oito pacientes (11,94 por cento), não podemos afirmar que todos os casos de meningite crônica sejam devidos à cisticercose, mas para qualquer caso de meningite crônica de origem desconhecida seria útil considerar a possibilidade de meningite por cisticerco.


Subject(s)
Animals , Humans , Antibodies, Helminth/cerebrospinal fluid , Antigens, Helminth/cerebrospinal fluid , Meningitis/parasitology , Neurocysticercosis/diagnosis , Agglutination Tests , Chronic Disease , Enzyme-Linked Immunosorbent Assay , Meningitis/cerebrospinal fluid , Meningitis/immunology , Neurocysticercosis/complications , Neurocysticercosis/immunology
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